Thursday, 10 September 2009
09:00 - 10:40 | Scientific Session 1 - Genetics
Chairs : Jean-Pierre Cézard (France), Rob Heuschkel (UK)
09:00 Pediatric IBD genes
Subra KUGATHASAN (Atlanta, GA, USA)
09:30 Epidemiology of pediatric IBD
Dominique TURCK (Lille, France)
10:00 Environmental risk factors - relevance for pediatric IBD
Sibylle KOLETZKO (Munich, Germany)
click here to download
10:30 CD1D-dependent regulation of bacterial colonization in the intestine
E. S. Nieuwenhuis, T. Matsumoto, D. Lindenbergh-Kortleve, S. Middendorp, R. Willemsen, A. Kaser, Y. Simons-Oosterhuis,
S. Brugman, K. Yamaguchi, H. Ishikawa, Y. Aiba, Y. Koga, J. Samsom, K. Oshima, M. Kikuchi, J. C. Escher, M. Hattori, A. B. Onderdonk, R. S. Blumberg (Rotterdam, The Netherlands) (O01)
Coffee break and visit of the exhibition 10:40 - 11:00
11:00 - 11:30 | State of the Art Lecture
Chairs : Jean-Pierre Cézard (France), Rob Heuschkel (UK)
11:00 Interaction genes - environment
Jean-Pierre HUGOT (Paris, France)
11:30 - 13:10 | Scientific Session 2 - Innate/Adaptive Immunity
Chairs : Frank Ruemmele (France), Matthieu Allez (France)
11:30 DC functions in IBD
Edward NIEUWENHUIS (Rotterdam, The Netherlands)
12:00 Autophagy and pediatric IBD
Ramnik XAVIER (Boston, MA, USA)
12:30 IL23/IL17 pathway in IBD
Fiona POWRIE (Oxford, UK)
13:00 NOD2 regulates the host response toward microflora by modulating T-cell function and epithelial permeabilityin
mouse peyer's patches
F. Barreau, C. Madre, D. Berrebi, G. Sterkers, S. Bonacorsi, T. Lesuffleur, J. P. Hugot (Paris, France ) (O02)
Lunch and visit of the posters 13:10 - 14:30
14:30 - 16:10 | Clinical Session 1 - (PART 1) Specific care for pediatric IBD
Chairs : Olivier Mouterde (France), Arie Levine (Israel)
14:30 Quality of life in pediatric IBD
Adrian THOMAS(Manchester, UK)
15:00 Treatment compliance and adolescence
Maria OLIVA-HEMKER (Baltimore, USA)
15:30 Stress in IBD
David RAMPTON (London, UK)
16:00 Efficacy of fractionated oral versus continuous enteral nutritional therapy in pediatric crohn's disease
A. Rubio, J. Schmitz, O. Goulet, F. Ruemmele (Nice, France) (O03)
Coffee break 16:10 - 16:30
16:30 - 18:20 | Clinical Session 1 - (PART 2) Specific care for pediatric IBD
Chairs : Hans Hildebrand (Sweden), Anne Griffiths (Canada)
16:30 And how to treat severe UC ?
Simon TRAVIS (Oxford, UK)
click here to download
17:00 Perianal and internal fistula - how to treat
Gert van ASSCHE (Leuven, Belgium)
click here to download
17:30 IBD Registries: triumphs and challenges
Jeff HYAMS (Hartford, USA)
click here to download
18:00 Incidence and prevalence of childhood-onset inflammatory bowel disease in Ontario, Canada:
results from the Ontario Crohn's and Colitis Cohort (OCCC)
E. I. Benchimol, A. Guttmann, A. M. Griffiths, L. Rabeneck, D. R. Mack, H. Brill, J. Howard, J. Guan, T. To(Toronto, Canada) (O04) click here to download
18:10 Epidemiology of growth impariment in paediatric IBD
T. D. Walters, M. Sherlock, T. Seah, M. Zachos, A. M. Griffiths (Toronto, Canada) (O05)
18:30 - 19:30 | Satellite Symposium: NESTLE NUTRITION INSTITUTE
RECENT FINDINGS IN ENTERAL NUTRITION: When are trends considered evidence?
Chair : Olivier Goulet (France)
18:30 The effect of enteral nutrition on microbiota, metabolites and faecal biomarkers
Paraic McGrogan (Scottland)
19:00 The effect of enteral nutrition on small intestinal mucosa assessed by capsule endoscopy
Paolo Lionetti (Florence, Italy)
Friday, 11 September 2009
09:00 - 10:40 | Clinical Session 2 - Therapeutic strategies for pediatric CD
Chairs : Hankje Escher (The Netherlands), Dick Grand (USA)
Duo step up-top down therapy and mucosal healing :
09:00 The view of the adult Gastroenterologist
Séverine VERMEIRE (Leuven, Belgium)
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09:30 The view of the pediatric Gastroenterologist
Arie LEVINE (Tel Aviv, Israel)
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10:00 Clinical Cases and treatment strategies
Paolo LIONETTI (Florence, Italy)
David MOORE (Adelaide, Australia)
10:30 Infliximab-induced psoriasis in paediatric crohn disease; experience at a tertiary centre and a potential association
with a variation in the IL-23 receptor gene
M. Sherlock, T. Walters, A. Muise, M. Zachos, A. Griffiths (Toronto, Canada) (O06)
Coffee break and visit of the exhibition 10:40 - 11:00
11:00 - 11:30 | State of the Art Lecture
Chairs : Sibylle Koletzko (Germany), Jacques Sarles (France)
11:00 New perspectives of biologicals in (pediatric) IBD
Daan W.HOMMES (Leiden, The Netherlands)
11:30 - 13:10 | Clinical Session 3 - Complications of IBD and related treatment
Chairs : Sibylle Koletzko (Germany), Jacques Sarles (France)
11:30 IBD and lymphoma
Laurent BEAUGERIE (Paris, France)
click here to download
12:00 HSTCL - does it matter for pediatric IBD ?
Salvatore CUCCHIARA (Rome, Italy)
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12:25 Opportunistic infections in IBD
Gigi VEEREMAN-WAUTERS (Antwerp, Belgium)
click here to download
12:50 Predictors of clinical outcome in children with ulcerative colitis (UC)
J. Markowitz, D. Mack, N. Leleiko, A. Otley, J. Evans, M. Pfefferkorn, M. Oliva-Hemker, W. Crandall, J. Rosh, M. Kappelman, D.Keljo, S. Kugathasan, T. Lerer, J. Hyams (Hartford, USA) (O07)
13:00 Methotrexate in the treatment of inflammatory bowel disease : an 8 year retrospective study in a canadian
pediatric IBD center
S. Willot, A. Noble, C. Deslandres (Montreal, Canada) (O08)
Lunch and visit of the posters 13:10 - 14:30
14:30 - 16:00 | Clinical Session 4 (PART 1)
Therapeutic strategies for pediatric CD : Evidence-based controversies
Chairs : Jorge Amil Dial (Portugal), Yu Kar Ling Koda (Brazil)
14:30 Induction therapy: EN, Steroids, Biologicals ?
Anne GRIFFITHS (Toronto, Canada)
click here to download
14:50 Maintenance therapy: Immunomodulation - when and how long ?
Rob HEUSCHKEL (Cambridge, UK)
15:10 And if Biologics change the natural history of CD ?
Bob BALDASSANO (Philadelphia, USA)
click here to download
15:30 Discussion
Coffee break and visit of the exhibition 16:00 - 16:30
Clinical session 4 (PART 2)
16:30 - 18:15 | Therapeutic strategies for pediatric CD : Evidence-based controversies
Chairs : Thierry Lamireau (France), Rob Baldassano (USA)
16:30 DUO: New treatment strategies :
Should we target the innate or the adaptive immune system ?Targeting the innate immune system
Claudio FIOCCHI (Cleveland, USA)
click here to download
Targeting the adaptive immune system
Matthieu ALLEZ (Paris, France)
17:30 Exposure to diagnostic imaging radiation in children under 8 years old with inflammatory bowel disease
K. Halamay, G. Wahbeh, M. Golchha, T. Chapman, D. Suskind (Seattle, USA) (O09)
17:40 Association between IL23R, ATG16L1, IRGM and NOD2 susceptibility genes and subphenotypes
on a large cohort of IBD patients
C. Jung, J. Colombel, L. Beaugerie, M. Lemann, J. Cezard, F. Ruemmele, D. Turck, H. Zouali, G. Thomas,
J. Hugot (Paris, France ) (O10)
17:50 How and why is pediatric IBD different from adult IBD ?
Hankje ESCHER (Rotterdam, NL)
18:10 Early-onset inflammatory bowel disease caused by loss-of-function mutations in the IL10-receptor genes
Erik-Oliver Glocker, Daniel Kotlarz, Kaan Boztug, E. Michael Gertz, Alejandro A. Schäffer, Fatih Noyan, Mario Perro, Jana Diestelhorst, Anna Allroth, Dhaarini Murugan, Nadine Hätscher,Dietmar Pfeifer, Karl-Walter Sykora, Martin Sauer, Hans Kreipe, Martin Lacher, Rainer Nustede,Cristina Woellner, Ulrich Baumann, Ulrich Salzer, Sibylle Koletzko, Neil Shah, Anthony W.Segal, Axel Sauerbrey, Stephan Buderus, Scott B. Snapper, Bodo Grimbacher, Christoph Klein (Germany) (O10B)
18:30 - 19:50 | Satellite Symposium: SCHERING-PLOUGH
REACHing High: Efficacy and Benefit: Risk Considerations With Infliximab in Paediatric CD
Chair : Frank Ruemmele (France)
Welcome and Introductions
Treating Pediatric Crohn's Disease Patients with Infliximab- the Local Experience
Frank Ruemmele, MD, PhD (Paris, France)
Long-term Efficacy Outcomes with Infliximab in Pediatric Crohn's Disease
Jeffrey S. Hyams, MD (Hartford, CT, USA)
Benefit:Risk Considerations with Infliximab in Pediatric Crohn's Disease
Salvatore Cucchiara, MD, PhD (Rome, Italy)
Question-and-Answer Session
Session Panel
Saturday, 12 september 2009
09:00 - 11:00 | Scientific Session 3 - Bacteria and IBD
Chairs : Olivier Goulet (France), Paolo Lionetti (Italy)
09:00 Is Crohn's Disease an Immunodeficiency?
Bu'Hussain HAYEE (London, UK)
09:30 What drives the flora to become pathogenic?
Philippe SEKSIK (Paris, France)
10:00 Microvascular inflammation - relevance for CD?
Silvio DANESE (Milano, Italy)
10:30 Curcumin suppresses P38 MAPK activation, reduces IL-1BETA and MMP-3, and enhances IL-10 expression in
the mucosa of patients with inflammatory bowel disease
J. Epstein, T. T. MacDonald, I. R. Sanderson (London, UK) (O11)
10:40 Hemin attenuates IL-17 production and experimental colitis
Z. Zhang, W. Zhong, D. J. Hinrichs, J. T. Rosenbaum (Portland, USA) (O12)
10:50 Immunohistochemical markers of small bowel inflammation in children with ulcerative colitis
L. Quaglietta, E. Giannetti, C. Aquino, F. Paparo, E. Miele, C. Friano, R. Troncone, A. Staiano (Naples, Italy) (O13)
11:00 - 12:00 | Scientific Session 3 (PART 2) - Bacteria and IBD
11:00 The most burning and yet unanswered questions in IBD
Marc LEMANN (Paris, France)
12:00 - 12:30 | Closing remarks
POSTERS
The posters will be displayed from Thursday 10 to Saturday 12 September.
There will be 2 poster visits : on Thursday 10 Sept. and Friday 11 Sept. from 13:10 to 14:30.
Click here to download all abstracts
Basic Science - Animal Models
P001 T-CELL REGULATION OF NEUTROPHIL INFILTRATE AT THE EARLY STAGES OF A MURINE COLITIS MODEL
P. E. van Lierop*, C. de Haar, D. Lindenberh-Kortleve, Y. Simons-Oosterhuis, L. van Rijt, B. Lambrecht, J. C. Escher,
J. N. Samsom, E. S. Nieuwenhuis (Rotterdam, Netherlands)
Basic Science - Genetics
P002 KIR GENES AS DETERMINANTS OF INNATE RESISTANCE/SUSCEPTIBILITY TO CROHN'S DISEASE
S. Samarani*, Z. Almalte, I. Alexandre, O. Debbeche, D. Amre, A. Ahmad (Montreal, Canada)
P003 THIOPURINE METHYL TRANSFERASE GENOTYPING OF A POPULATION OF CHILDREN WITH IBD
S. Pissarra*, E. Trindade, J. C. Machado, J. Amil Dias (Porto, Portugal)
P004 DNA REPAIR MECHANISMS IN PAEDIATRIC INFLAMMATORY BOWEL DISEASES
C. Bascietto*, P. Fortini, E. Dogliotti, M. Bignami, I. Casorelli, F. Chiera, F. Foschia, P. De Angelis, E. Romeo,
F. Torroni, L. Dall'Oglio (Rome, Italy)
P005 ATG16L1 RS2241880 G ALLELE AND IL23R RS11209026 (ARG381GLN) VARIANT ARE ASSOCIATED
WITH CROHN´S DISEASE IN GERMAN CHILDREN
M. Lacher*, S. Schroepf, J. Helmbrecht, S. Osterrieder, D. von Schweinitz, A. Ballauff, P. Lohse,
R. Kappler, S. Koletzko (Munich, Germany)
P006 RICK/RIP2 POLYMORPHISMS IN INFLAMMATORY BOWEL DISEASES
R. Thiébaut*, V. Douchin, F. Merlin, J. Colombel, M. Lemann, S. Almer, C. Tysk, M. Omorain, M. Gassull, V. Binder,
Y. Finkel0, C. Jung, L. Pascoe, J. Hugot (Paris, France)
Basic Science - Immunology
P007 IS THERE A ROLE FOR CYTOKINES IN THE PATHOGENESIS OF DEPRESSED MOOD IN CROHN'S DISEASE?
O. Guilbaud*, M. Lemann, Y. Bouhnik, M. Bellaiche, M. Corcos (Paris, France)
P008 DETERMINATION OF IGG AND IGA ANTIBODIES AGAINST HELICOBACTER PYLORI IN CHILDREN OF PRESCHOOL
AND SCHOOL AGE
A. Triantafyllopoulou*, S. Patiakas, I. Alexidis (Kastoria,Greece)
P009 DETERMINANTS OF CORTICOSTEROID-RESISTANCE IN SEVERE PEDIATRIC ULCERATIVE COLITIS
D. Turner*, E. Wine, K. Kolho, T. Raivio, D. Mack, J. Hyams, M. Silverberg, A. Otley, J. Markowitz, W. Crandall, P. Mamula,
N. Leleiko, A. M. Griffiths (Israel)
P010 PANETH CELLS: A SOURCE OF THE PRO-INFLAMMATORY CYTOKINE TNF-ALPHA
P. van Lierop*, S. Middendorp, D. Lindenberh-Kortleve, J. Samsom, J. Escher, E. Nieuwenhuis (Rotterdam, Netherlands)
Basic Science - Inflammation
P011 FAECAL OSTEOPROTEGRIN IN PAEDIATRIC CROHN DISEASE
A. S. Day*, L. Nahidi, S. T. Leach, M. Sidler, A. Levin, D. A. Lemberg (Randwick, Australia)
P012 PHOSPHOLIPIDS AND COLITIS: IMPACT OF LACK OF BILIARY AND NUTRITIONAL PHOSPHOLIPIDS
ON CHEMICALLY INDUCED COLITIS IN MICE
J. Jahnel*, T. Claudel, A. Baghdasaryan, D. Silbert, J. Gumhold, A. Fuchsbichler, C. Langner, M. Trauner (Graz, Austria)
P013 PERIPHERAL VENOUS THROMBOSIS COMPLICATING ULCERATIVE COLITIS
N. Siala*, O. Rebah, M. Ben Hariz, A. Maherzi (La Marsa,Tunisia)
P014 ANTI-INFLAMMATORY ROLE OF IL-27 IN TNF-ALPHA INDUCED INTESTINAL INFLAMMATION
X. Tian, C. Rajendra, S. Kugathasan (Atlanta, United States)
Clinical Science - Clinical Trial
P015 HIGH RESOLUTION COMPUTED TOMOGRAPHY AND PULMONARY FUNCTION TESTS IN CHILDREN WITH
INFLAMMATORY BOWEL DISEASES. A PILOT STUDY
J. Peradzynska*, K. Krenke, J. Lange, I. Lazowska-Przeorek, A. Banaszkiewicz, P. Albrecht, M. Kulus, A. Radzikowski (Warsaw, Poland)
P016 IDIOPATHIC PANCREATITIS BEFORE INFLAMMATORY BOWEL DISEASE IS MORE FREQUENT IN PEDIATRIC PATIENTS
E. Broide*, B. Weiss, A. Levine (Beer Yaakov, Israel)
P017 QUALITY OF LIFE AT RESTORATIVE COLECTOMY AND ILEAL POUCH ANAL ANASTOMOSIS FOR ULCERATIVE
COLITIS IN CHILDREN: PRELIMINARY RESULTS
E. Ceriati*, F. De Peppo, M. Rivosecchi (Rome, Italy)
P018 FACTORS INFLUENCING FINAL HEIGHT IN PAEDIATRIC IBD PATIENTS
G. Cont*, E. Da Dalt, P. Salierno, S. Martelossi, A. Ventura (Trieste, Italy)
P019 MICROSCOPIC COLITIS IN CHILDREN
W. El-Matary*, S. Girgis, H. Huynh, J. Turner, B. Diederichs (Edmonton, Canada)
P020 TRACE ELEMENTS, VITAMIN STATUS AND BONE DENSITY AT DIAGNOSIS IN CHILDREN WITH INFLAMMATORY
BOWEL DISEASE
S. Sikora*, H. Huynh, J. Turner, R. Persad, W. El-Matary (Edmonton, Canada)
P021 TRANSIENT HYPERTRANSAMINASEMIA IN PEDIATRIC PATIENTS WITH CROHN'S DISEASE UNDERGOING
INITIAL TREATMENT WITH ENTERAL NUTRITION
H. Hoekstra*, E. J. H. Schatorjé ('S-Hertogenbosch, Netherlands)
P022 CHARACTERISTICS OF PAEDIATRIC IBD PATIENTS AT TWO DISTANT 5-YEARS PERIODS: SINGLE CENTRE REPORT
I. Hojsak*, Z. Misak, O. Jadresin, S. Abdovic, A. Jaklin Kekez, S. Kolacek (Zagreb, Croatia)
P023 CROHN'S DISEASE PRESENTATION IN PEDIATRIC PATIENTS
C. Jung*, J. Colombel, L. Beaugerie, M. Lemann, J. Cezard, F. Ruemmele, D. Turck, H. Zouali, G. Thomas,
J. Hugot (Paris, France)
P024 EFFECT OF FORMALN2%ON SOLITARY RECTAL ULCER IN PEDIATRIC
E. Khorasani* (Kermanshah, Iran)
P025 CHARACTERISTICS OF INFLAMMATORY BOWEL DISEASE IN BRAZILIAN CHILDREN 5 YEARS OF AGE AND YOUNGER
Y. K. L. Koda*, E. Vidolin, L. Okamoto, K. Murasca (Sao Paulo, Brazil)
P026 PRESENTATION OF INFLAMMATORY BOWEL DISEASE IN BRAZILIAN PATIENTS 0-5 COMPARED TO
6-17 YR OF AGE AT DIAGNOSIS
Y. K. L. Koda*, E. Vidolin, L. Okamoto, K. Murasca (Sao Paulo, Brazil)
P027 FECAL CALPROTECTIN MIRRORS INFLAMMATION OF THE PULLED THROUGH ILEUM AND BOWEL FUNCTION
AFTER RESTORATIVE PROCTOCOLECTYMY FOR PEDIATRIC ONSET ULCERATIVE COLITIS
M. Pakarinen*, A. Koivusalo, J. Natunen, M. Ashorn, R. Karikoski, P. Aitola, R. Rintala, K. Kolho (Helsinki, Finland)
P028 THALIDOMIDE FOR TREATING REFRACTORY CROHN'S DISEASE AND ULCERATIVE COLITIS IN CHILDREN:
RANDOMIZED CONTROLLED TRIAL (PRELIMINARY RESULTS)
M. Lazzerini*, S. Martelossi, M. Maschio, F. Marchetti, M. Bramuzzo, G. Magazzu, G. Scibilia, A. Barabino, A. Calvi, M. Fontana, P. Lionetti, F. Mangiantini, M. Lorusso, G. Palla, G. Maggiore, V. Villanacci, F. Bartoli, G. Decorti, S. De Iudicibus, M. Montico,
R. Paparazzo, A. Ventura (Italy)
P029 COEXISTENCE OF PYODERMA GANGRENOSUM AND SWEET'S SYNDROME IN CROHN'S DISEASE. CASE REPORT
J. Martín de Carpi*, P. Vilar, V. Varea (Barcelona, Spain)
P030 THIOPURINE SUPRESSION IN PAEDIATRIC CROHN'S DISEASE PATIENTS ON COMBINATION THERAPY WITH ANTI-TNF
J. Martín de Carpi*, N. Pociello, V. Varea (Barcelona, Spain)
P031 DIAGNOSTIC ACCURACY OF FECAL CALPROTECTIN ASSAY IN DISCRIMINATING FUNCTIONAL FROM ORGANIC
BOWEL DISEASES IN PEDIATRIC PATIENTS
C. Noto*, A. Diamanti, F. Colistro, M. S. Basso, F. Bracci, B. Papadatou, P. Francalanci, D. Knafelz, F. Ferretti, F. Torroni,
M. Castro (Rome, Italy)
P032 SURGERY FOR CROHN'S DISEASE IN CHILDREN IMPROVES GROWTH AND NUTRITION BUT CARRIES
A HIGH RELAPSE RATE
M. Pacilli*, S. Eaton, J. Fell, D. Rawat, S. Clarke, M. Haddad (London, United Kingdom)
P033 IS PAEDIATRIC-ONSET CROHN'S DISEASE MORE SEVERE?
B. Pigneur*, J. Girardet, P. Seksik, J. Cosnes (Paris, France)
P034 CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS IN FOUR CHILDREN WITH INFLAMMATORY BOWEL DISEASE
C. Prell*, A. Jansson, S. Osterrieder, S. Koletzko (Munich, Germany)
P035 LONGITUDINAL ASSESSMENT OF BONE MINERAL DENSITY IN A POPULATION OF CHILDREN AND ADOLESCENTS
WITH INFLAMMATORY BOWEL DISEASE
S. Schmidt*, D. Mellström, E. Norjavaara, V. Sundh, R. Saalman (Göteborg, Sweden)
P036 PHOSPHATE, CALCIUM AND ALKALINE PHOSPHATASE LEVELS IN PEDIATRIC AND ADULT PATIENTS
WITH INFLAMMATORY BOWEL DISEASE
S. Shehada, I. Chermesh, A. Lanir, R. Shaoul* (Haifa, Israel)
P037 LONG-TERM EFFICACY AND SAFETY OF MAINTENANCE INFLIXIMAB THERAPY FOR THE TREATMENT OF
MODERATE-TO-SEVERE PEDIATRIC CROHN'S DISEASE: RESULTS FROM THE REACH STUDY
G. Veereman-Wauters*, R. Baldassano, M. Blank, W. Crandall, A. Griffiths, R. Heuschkel, T. D. Walters,
J. Hyams (Antwerp, Belgium)
P038 RESPONSE TO MEDICAL TRESTMENT IN PATIENTS WITH CROHN'S DISEASE
B. Weiss*, O. Leibovitz, H. Fidder, A. Levine, R. Shaoul, S. Reif, Y. Bujanover, A. Karban (Tel-Aviv, Israel)
P039 LONG-TERM DEVELOPMENT OF BONE AND MUSCLE IN PEDIATRIC IBD PATIENTS
K. J. Werkstetter*, S. Bechtold-Dalla Pozza, B. Filipiak-Pittroff, P. Bufler, B. Koletzko, S. Koletzko (Munich, Germany)
P040 CLINICAL ANALYSIS OF 23 INFLAMMATORY BOWEL DISEASE CASES IN CHILDREN
Y. Zhou, Y. Huang* (Shanghai, China)
Clinical Science - Diagnosis
P041 IS OROFACIAL CROHN'S DISEASE A DISTINCTIVE PHENOTYPE IN AN AUSTRALIAN PAEDIATRIC COHORT?
R. Abu-Assi*, E. Yeung, S. Gue, P. Baghurst, D. Moore (Adelaide, Australia)
P042 EXPRESSION LEVELS OF LEUKOTRIENE B4 RECEPTOR IN CROHN'S DISEASE
C. Babakissa*, J. Plante, S. Turcotte, M. Rola-Pleszczynski (Sherbrooke, Canada)
P043 COLONIC STRICTURES IN PAEDIATRIC CROHN'S DISEASE: A 15YR TERTIARY CENTRE EXPERIENCE
D. Basude*, G. Haddock, P. Raine, P. McGrogan, K. O. Hassan (Bristol, United Kingdom)
P044 IDENTIFYING CHILDREN DIAGNOSED WITH IBD USING HEALTH ADMINISTRATIVE DATA: DEVELOPMENT
OF THE ONTARIO CROHN'S AND COLITIS COHORT (OCCC)
E. I. Benchimol*, A. Guttmann, A. M. Griffiths, L. Rabeneck, D. R. Mack, H. Brill, J. Howard, J. Guan, T. To (Toronto, Canada)
P045 EXTENSION OF UC/CD IN PEDIATRIC PSC
T. Martensson, F. Lindgren, M. Hessami, B. Fischler, A. Németh, T. Casswall* (Sto, Sweden)
P046 ARE CHILDREN WITH INFLAMMATORY BOWEL DISEASE REACHING THEIR TARGET HEIGHT AT AN ADULT AGE?
A COHORT STUDY
G. Damen*, R. van Rheenen, J. Tolboom, B. Otten, D. de Jong, J. van der Woude, E. Nieuwenhuis,
J. Escher (Nijmegen, Netherlands)
P047 SERUM 25-HYDROXY-VITAMIN D DEFICIENCY IN AUSTRALIAN CHILDREN WITH IBD
A. S. Day*, A. Levin, V. Wadhera, S. T. Leach, H. Woodhead, C. Mendoza-Cruz, D. A. Lemberg (Randwick, Australia)
P048 SMALL BOWEL CAPSULE ENDOSCOPY IN PEDIATRIC PATIENTS: FIRST TEN PATIENTS
A. Derovs, I. Eglite*, J. Derova, J. Pokrotnieks (Riga, Latvia)
P049 INFANTILE COLITIS; EVALUATION OF 19 CASES
O. Egritas*, S. Sari, B. Dalgic (Ankara,Turkey)
P050 WIRELESS CAPSULE ENDOSCOPY: IMPLICATIONS ON DIAGNOSIS AND THERAPY IN PAEDIATRIC ONSET CROHN'S DISEASE
N. Giurici*, S. Martelossi, G. Di Leo, S. Pastore, D. Giglia, E. Franceschi, A. Ventura (Trieste, Italy)
P051 INFLAMMATORY BOWEL DISEASE: DIFFERENT AGE CLASSES IN COMPARISON
G. Guariso*, M. Gasparetto, L. Visona Dalla Pozza, F. Brotto, R. D'Inca, L. Zancan, G. Sturniolo, P. P. F. Facchin (Padua, Italy)
P052 CHARACTERISTICS AND PECULIARITIES OF CHILDHOOD-ONSET IBD
G. Guariso*, F. Brotto, M. Gasparetto, L. Visona Dalla Pozza, R. D'Inca, L. Zancan, G. Sturniolo, P. Facchin (Padua, Italy)
P053 TWO INDEPENDENT ASSOCIATIONS ON THE IBD5 LOCUS WITH CROHNS DISEASE IN THE CZECH POPULATION
O. Hradsky*, P. Dusatkova, M. Lenicek, J. Bronsky, J. Nevoral, L. Vitek, M. Lukas, O. Cinek (Prague, Czech Republic)
P054 GUT INFLAMMATION IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS
F. Kiparissi*, C. Ong, M. Elawad (London, United Kingdom)
P055 INDETERMINATE COLITIS (IC) - A SINGLE CENTER EXPERIENCE
F. Kiparissi*, A. Kader, M. Elawad (London, United Kingdom)
P056 EVALUATION OF METALLOPROTEINASE 3 AND 9 CONCENTRATION IN SERUM OF CHILDREN WITH ULCERATIVE COLITIS
A. Kofla-Dlubacz*, M. Matusiewicz, B. Iwanczaknd (Wroclaw, Poland)
P057 EVALUATION OF METALLOPROTEINASE 3 AND 9 CONCENTRATION IN SERUM OF CHILDREN WITH CROHN'S DISEASE
A. Kofla-Dlubacz*, M. Matusiewicz, B. Iwanczaknd (Wroclaw, Poland)
P058 LUNG MEMBRANE DIFFUSION AND CAPILLARY VOLUME IN CROHN'S DISEASE: A PILOT STUDY
T. Lamireau*, M. Choukroun, L. Rebouissoux, H. Clouzeau, G. Masse, S. Bui, M. Fayon (Bordeaux, France)
P059 INCREASING CUMULATED PREVALENCE OF INFLAMMATORY BOWEL DISEASE IN CHILDREN AT
NORTH-WESTERN MEXICO: EPIDEMIOLOGICAL TRANSITION
A. Larrosa*, A. Magallanes, R. Macías, C. Bojórquez, O. García, A. Celis (Guadalajara, Mexico)
P060 CLINICAL FEATURES AND OUTCOME OF CHILDHOOD CROHN DISEASE FROM A MULTI-ETHNIC ASIA POPULATION
W. S. Lee*, Y. S. Hoh, P. F. Chai, C. C. M. Boey (Kuala Lumpur, Malaysia)
P061 LIVING WITH INFLAMMATORY BOWEL DISEASE AS AN ADOLESCENT
H. M. Lindfred*, R. Saalman, S. Nilsson, M. Lepp (Göteborg, Sweden)
P062 RADIOLOGIC EVALUATION OF THE SMALL INTESTINE IN PEDIATRIC INFLAMMATORY BOWEL DISEASE
A. Linnér*, P. Malmborg, U. Ullberg, U. L. Fagerberg, H. Hildebrand (Stockholm, Sweden)
P063 MARKERS OF PERINATAL BOWEL COLONIZATION AND PEDIATRIC CROHN'S DISEASE RISK
P. Malmborg*, H. Hildebrand, A. Kling, S. M. Montgomery (Stockholm, Sweden)
P064 APPLICATION OF THE PORTO CRITERIA FOR DIAGNOSIS OF PAEDIATRIC IBD IN A REFERRAL PAEDIATRIC CENTRE
J. Martín de Carpi*, P. Vilar, V. Varea (Barcelona, Spain)
P065 MISDIAGNOSED CROHN'S DISEASE IN AN ADOLESCENT WITH SHORT STATURE
N. Miu*, B. Simionescu, P. Florescu (Cluj Napoca, Romania)
P066 UPPER GASTROINTESTINAL INVOLVEMENT IN PEDIATRIC CROHN´S DISEASE
S. B. Osterrieder*, P. Bufler, K. Werkstetter, S. Koletzko (Munich, Germany)
P067 MRI-MONITORING OF DISEASE-ACTIVITY AND RESPONSE TO THERAPY IN PEDIATRIC INFLAMMATORY BOWEL DISEASE
A. Pappas*, S. Jansen, C. Hohl, D. Honnef, R. Winograd, N. Wagner, T. G. Wenzl (Aachen, Germany)
P068 ALPHA-DEFENSIN HD-5 AND WNT SIGNALLING TCF-4 IN PEDIATRIC PATIENTS WITH CROHN´S DISEASE
G. Perminow*, J. Beisner, M. Koslowski, L. G. Lyckander, E. Stange, M. H. Vatn, J. Wehkamp (Oslo, Norway)
P069 INFLAMMATORY BOWEL DISEASE AND GLYCOGEN STORAGE DISEASE
M. Rafeey*, A. Javadzadeh, F. Javadzadeh (Tabriz, Iran)
P070 SMALL INTESTINE CONTRAST ULTRASONOGRAPHY IN PRE-SURGICAL ASSESSMENT OF BOWEL STRICTURES
IN PAEDIATRIC CROHN'S DISEASE PATIENTS: 2 CASE REPORTS
E. Romeo*, N. Pallotta, P. De Angelis, T. Caldaro, G. Federici di Abriola, F. Foschia, F. Torroni, L. Dall'Oglio (Rome, Italy)
P071 DXA'S AIN'T DXA'S- TAKING A CLOSER LOOK AT BONE HEALTH IN PEDIATRIC INFLAMMATORY BOWEL DISEASE (IBD)
J. Rosenbaum*, A. G. Catto-Smith, M. R. Oliver, M. Zacharin (Parkville, Australia)
P072 A NEW JOINT INFLAMMATORY BOWEL DISEASE TRANSITION SERVICE
N. Morgan*, K. Greveson, C. Murray, F. Torrente, C. Salvestrini (London, United Kingdom)
P073 LONGITUDINAL STUDY OF BONE MINERAL DENSITY SINCE THE DIAGNOSIS OF CROHN'S DISEASE
F. Samson*, B. Cagnard, E. Leray, P. Guggenbuhl, L. Bridoux-Henno, A. Dabadie (Rennes, France)
P074 BLUNT ABDOMINAL TRAUMA REVEALING A SEALED PERFORATION IN STEROID-DEPENDENT CROHN'S DISEASE
A CASE REPORT
D. Scholz*, M. Hirschburger, G. F. P. Alzen, K. P. Zimmer (Giessen, Germany)
P075 CROHN'S DISEASE IN TUNISIAN CHILDREN: A MULTICENTER STUDY OF 50 CASES
N. Siala*, A. Benzarti, M. Hachicha, M. Guddiche, S. Bousnina, T. Sfar, S. Ben Becher, A. Sammoud, R. Lakhoua,
S. Essoussi, N. Gandoura, A. Bouaziz, F. Bayoudh, A. Harbi, M. Ben Hariz, A. Maherzi (La Marsa, Tunisia)
P076 DETERMINANTS OF DISEASE LOCATION IN PAEDIATRIC CROHN'S DISEASE - EFFECT OF AGE
AND SEX IN THE CEDATA-REGISTRY
A. Timmer*, P. Rzehak, W. Lohr, T. Cedata (München, Germany)
P077 IMAGING OF THE SMALL INTESTINE WITH THE USE OF ENTEROCLYSIS IN CHILDREN WITH INFLAMMATORY
BOWEL DISEASES
E. Toporowska-Kowalska*, B. Gebora-Kowalska, J. Kudzin, A. Plocek, E. Biernacka, K. Wsowska-Królikowska
(Lodz, Poland)
P078 NUTRITIONAL STATUS AND GROWTH IN PEDIATRIC CROHN'S DISEASE (CD): A POPULATION BASED STUDY
F. Vasseur, C. Gower-Rousseau, G. Vernier-Massouille, J. Dupas, V. Merle, B. Merlin, E. Lerebours, G. Savoye,
J. Salomez, A. Cortot, J. Colombel, D. Turck* (Lille, France)
P079 EARLY ONSET IBD AND IBD MIMICKING COLITIS
K. Uchida*, M. Inoue, K. Ohtake, Y. Koike, K. Matsushita, T. Araki, S. Yoshiyama, Y. Ohkita, K. Tanaka, C. Miki,
M. Kusunoki (Tsu, Japan)
P080 PEDIATRIC INFLAMMATORY BOWEL DISEASE, REVIEW OF 22 CASES FROM TURKEY
P. Urenden*, G. Kutluk, D. Ertem, E. Pehlivanoglu (Istanbul, Turkey)
P081 PANCREATIC ANTIBODIES ARE ASSOCIATED WITH ANTI-SACCHAROMYCES CEREVISIAE ANTIBODIES AND MORE
COMPLICATED DISEASE PHENOTYPE BUT NOT WITH NOD2/CARD15 MUTATIONS IN PEDIATRIC CROHN'S DISEASE
D. Urlep-Zuzej*, J. Dolinsek, D. Micetic-Turk (Maribor, Slovenia)
P082 IBD-ASSOCIATED ANEMIA IN CHILDREN: CONTROLLING INTESTINAL INFLAMMATION IS NOT ENOUGH
TO NORMALIZE HEMOGLOBIN
L. Pels, E. Van de Vijver, H. Waalkens, J. Uitentuis, G. Gonera-de Jong, L. van Overbeek, O. Norbruis, E. Rings, P. van Rheenen* (Groningen, Netherlands)
P083 PROFILE OF BELGIAN PEDIATRIC CROHN'S DISEASE SUBJECTS (1): DEMOGRAPHY AND BACKGROUND
OF THE FIRST 100 PATIENTS
G. Veereman* (Antwerp, Belgium)
P084 PROFILE OF BELGIAN PEDIATRIC CROHN'S DISEASE SUBJECTS (2): SNAP SHOT AT DIAGNOSIS
G. Veereman* (Antwerp, Belgium)
P085 CHARACTERISTICS OF 264 PROSPECTIVELY DIAGNOSED PATIENTS WITH INFLAMMATORY BOWEL DISEASE (IBD)
IN THE NATIONAL IBD REGISTRY
G. Veres*, M. Papp, P. Lakatos (Budapest, Hungary)
P086 MAGNETIC RESONANCE ENTEROGRAPHY USE IN PEDIATRIC IBD: REVIEW OF 20 PATIENTS
G. Ishak*, N. Yee, G. Wahbeh (Seattle, United States)
P087 THE FREQUENCY OF GRANULOMAS IN CHILDREN WITH CROHN'S DISEASE
M. Cieszkowska, J. Cieslik, P. Barud, K. Borek, A. Wedrychowicz, K. Kowalska-Duplaga* (Krakow, Poland)
P088 USE OF INFLAMMATORY BOWEL DISEASE (IBD)- ASSOCIATED SEROLOGIC MARKERS FOR SCREENING
OF CHILDREN AND ADOLESCENTS SUSPECT OF HAVING IBD
C. L. Weems*, J. R. Poley (Greenville, United States)
P089 SEUM PRO-HEPCIDIN MEASURMENT IS NOT A RELIABLE METHOD TO DEFINE THE CAUSE OF IRON DEFICIENCY ANEMIA
IN PEDIATRIC INFLAMMATORY BOWEL DISEASE PATIENTS
B. Weiss*, E. Shostak, O. Pikar, Y. Bujanover (Tel-Aviv, Israel)
P090 TRANSITION OF PAEDIATRIC IBD PATIENTS TO ADULT IBD SERVICES IN A REGIONAL COHORT 1997-2008
P. Rogers, S. Aitken, I. Arnott, J. Satsangi, D. C. Wilson* (Edinburgh, United Kingdom)
P091 ULTRASONOGRAPHIC ASSESSMENT OF ULCERATIVE COLITIS IN CHILDREN: COLONIC WALL THICKNESS
CORRESPONDS TO ENDOSCOPIC AND HISTOLOGIC ACTIVITY
A. Yoden*, M. K. Sugimoto, H. Tamai (Takatsuki, Japan)
Clinical Science - Drugs
P092 EFFICACY OF METOTHREXATE IN INDUCTION AND MAINTENANCE OF REMISSION IN PEDIATRIC CROHN'S DISEASE
S. Abdovic*, Z. Misak, I. Hojsak, S. Kolacek (Zagreb, Croatia)
P093 LONG TERM INFLIXIMAB IN CROHN'S DISEASE. NEW STRATEGIES ARE NEEDED?
I. Loureiro*, P. Soares, E. Trindade, S. Pissarra, J. Amil Dias (Porto, Portugal)
P094 PATTERNS OF COMPLEMENTARY AND ALTERNATIVE MEDICINE USE IN A POPULATION OF PEDIATRIC
PATIENTS WITH INFLAMMATORY BOWEL DISEASE
Y. Bujanover*, Y. Shostak (Ramat Gan, Israel)
P095 RECURRENT PANCREATITIS AND INFLAMMATORY BOWEL DISEASE IN AN ADOLESCENT:
EXTRAINTESTINAL MANIFESTATION OR DRUG RELATED?
F. Gurakan*, H. Demir, N. Uslu, U. Yusuf, S. Boyacioglu (Ankara, Turkey)
P096 FREQUENCY OF STEROID DEPENDENCY AND IMPACT ON DISEASE COURSE IN PAEDIATRIC
INFLAMMATORY BOWEL DISEASE. A POPULATION BASED COHORT STUDY
C. Jakobsen*, A. Paerregaard, P. Munkholm, V. Wewer (Hvidovre, Denmark)
P097 THE USE OF INFLIXIMAB IN THE TREATMENT OF REFRACTORY INFLAMMATORY BOWEL DISEASE IN CHILDREN
F. Kiparissi*, M. Elawad, K. Lindley (London, United Kingdom)
P098 PREVENTION OF ACUTE ADVERSE EVENTS RELATED TO INFLIXIMAB INFUSIONS IN PEDIATRIC PATIENTS
P. Lahdenne, A. Wikström, K. Aalto, K. Kolho* (Helsinki, Finland)
P099 PREDNISONE IN THE FIRST YEAR AFTER DIAGNOSIS OF CROHN DISEASE - PROSPECTIVE EVALUATION
OF THE TREATMENT STRATEGY
J. Maly*, O. Pozler, P. Dedek (Hradec Kralove, Czech Republic)
P100 HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN AN ADOLESCENT WITH CROHN'S DISEASE ON AZATHIOPRINE
P. Narula*, D. I. Campbell, M. Thomson, C. J. Taylor, S. Connolly (Leeds, United Kingdom)
P101 LONG-TERM TREATMENT WITH AUTOLOGOUS RED BLOOD CELLS LOADED WITH DEXAMETHASONE 21-PHOSPHATE
IN PEDIATRIC PATIENTS AFFECTED BY STEROID-DEPENDENT CROHN DISEASE AND ULCERATIVE COLITIS
B. Papadatou*, L. Rossi, F. Bracci, D. Knafelz, C. Noto, A. Diamanti, A. Filoni, M. Rossi, F. Ferretti, M. Magnani,
M. Castro (Roma, Italy)
P102 NEW MEANS TO MONITOR THE EFFECT OF GLUCOCORTICOID THERAPY IN CHILDREN
H. Rintamäki*, H. M. Salo, O. Vaarala, K. Kolho (Helsinki, Finland)
P103 CLINICAL SERIOUS ADVERSE EVENTS OF INFLIXIMAB IN PEDIATRIC INFLAMMATORY BOWEL DISEASE :
A LONG TERM RETROSPECTIVE STUDY
S. Roche*, E. Ecochard, C. Martinez-Vinson, J. Hugot, M. Bellaiche, V. Degas, J. Viala, E. Jacqz-Aigrain,
J. Cézard (Paris, France)
P104 A NATIONWIDE AUDIT OF ADALIMUMAB USE AND SAFETY IN CHILDREN WITH CROHN'S DISEASE
R. K. Russell*, M. L. Wilson, N. Shah, G. Mahdi, W. Hyer, C. Spray, I. Davies, R. Heuschkel, M. Green, A. Rodrigues,
F. Torrente, N. Ayub, J. Fell, S. Naik, D. C. Wilson (Glasgow, United Kingdom)
P105 AUTOLOGOUS HAEMATOPOIETIC STEM CELL TRANSPLANTATION IN A 4-YEAR-OLD MALE WITH REFRACTORY
CROHN'S DISEASE
O. Segarra*, T. Olivé, J. Broto, R. Tormo, C. Díaz de Heredia, D. Infante (Barcelona, Spain)
P106 CLINICAL BENEFITS AND PATTERN OF INFLIXIMAB USE TO OPTIMIZE TREATMENT EFFICACY IN PEDIATRICS IBD
PATIENTS - A SINGLE CENTER EXPERIENCE
M. K. Sladek*, A. Swiat, S. Pieczarkowski, K. Fyderek (Krakow, Poland)
P107 WITHDRAWAL OF IMMUNOSUPPRESSORS IN PAEDIATRIC IBD-PATIENTS TREATED WITH INFLIXIMAB IS POSSIBLE
J. Svahn*, L. Grahnquist (Lund, Sweden)
P108 INTRAVENOUS IRON SUCROSE IN CHILDREN WITH INFLAMMATORY BOWEL DISEASES
E. Toporowska-Kowalska*, B. Gebora-Kowalska, A. Plocek, J. Kudzin, E. Biernacka,
K. Wsowska-Królikowska (Lodz, Poland)
P109 EFFICACY AND SAFETY OF INFLIXIMAB THERAPY IN CHILDREN WITH INFLAMMATORY BOWEL DISEASES
OWN EXPERIENCE
E. Toporowska-Kowalska*, E. Biernacka, J. Kudzin, B. Gebora-Kowalska, A. Plocek,
K. Wsowska-Królikowska (Lodz, Poland)
P110 BIOLOGICAL THERAPY IN CHILDREN
F. Vincenzi*, B. Bizzarri, V. Maffini, G. de' Angelis (Parma, Italy)
P111 BIOLOGICAL THERAPY FOR PAEDIATRIC IBD IN SCOTLAND 1/00-12/08: A NATIONWIDE REAL LIFE EXPERIENCE
D. C. Wilson*, M. L. Wilson, N. Basheer, A. Jamison, D. Goudie, G. Mahdi, R. K. Russell (Edinburgh, United Kingdom)
P112 EXPRESSION PROFILE OF PROTEASES AND THEIR INHIBITORS IN THE INTESTINAL MUCOSA OF IBD ANIMAL MODELS
Daniel Lottaz*, Carlo Largiader, Giovanni Monteleone, Monica Boirivant, Christoph Müller, Stefan Wyder (Bern, Switzerland)